Imaging spectrum, associations and outcomes in acute invasive fungal rhino-ocular-cerebral sinusitis in patients with COVID-19 pneumonia

Imaging spectrum, associations and outcomes in acute invasive fungal rhino-ocular-cerebral sinusitis in patients with COVID-19 pneumonia

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Background: Coronavirus Disease 2019 (COVID-19) has been speculated to enhance mucormycosis infection due to its immune-altering pathophysiology.Early identification of high-morbidity conditions is crucial for optimal treatment diegojavierfares.com and improved outcomes.Methods: A retrospective study was conducted on 63 patients with clinical and microbiological evidence of rhino-ocular-cerebral mucormycosis, who had a history of COVID-19 infection.

The clinical, demographic, and imaging data were retrieved and analyzed.Descriptive statistics (mean [SD] and frequency [%]) were used to describe important characteristics across audit cycles.Results: Out of 63 patients, 54 (85.

71%) patients had associated comorbidities, with diabetes mellitus being common comorbidity and all patients had received injectable and/or oral corticosteroids.Imaging showed nasal and paranasal sinus, perisinus, maxillary alveolar arch, and hard palate involvement in 62 (98.41%), 33 (52.

38%), 5 (7.94%) and 5 (7.94%) patients, respectively.

Orbital involvement was seen in 24 (38.10%) patients.Skull base involvement was seen in 11 (17.

46%) patients, and intracranial extension of disease was present in arcade smokey the bear belt 11 (17.46%) patients.A total of 16 patients were on mechanical ventilation, of whom 3 succumbed.

The mean (standard deviation [SD]) intensive care unit (ICU) stay was 13.2 days (6.8) for 5 patients who succumbed and 6.

4 days (4.6) for 30 patients who survived (P value = 0.008).

Conclusion: Cross-sectional imaging not only provides the extent of disease spread but also plays a vital role in providing a surgical roadmap to treating surgeons and in predicting prognosis in patients with invasive fungal infections.